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CACNG1

CACNG1
Identifiers
AliasesCACNG1, CACNLG, calcium voltage-gated channel auxiliary subunit gamma 1
External IDsOMIM: 114209 MGI: 1206582 HomoloGene: 582 GeneCards: CACNG1
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for CACNG1
Genomic location for CACNG1
Band17q24.2Start67,044,554 bp[1]
End67,056,797 bp[1]
RNA expression pattern
PBB GE CACNG1 206612 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000727

NM_007582

RefSeq (protein)

NP_000718

NP_031608

Location (UCSC)Chr 17: 67.04 – 67.06 MbChr 11: 107.7 – 107.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Voltage-dependent calcium channel gamma-1 subunit is a protein that in humans is encoded by the CACNG1 gene.[5][6]

L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two similar gamma subunit-encoding genes.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108878 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020722 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Iles DE, Segers B, Sengers RC, Monsieurs K, Heytens L, Halsall PJ, Hopkins PM, Ellis FR, Hall-Curran JL, Stewart AD, et al. (Oct 1993). "Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility". Hum Mol Genet. 2 (7): 863–8. doi:10.1093/hmg/2.7.863. PMID 8395940.
  6. ^ a b "Entrez Gene: CACNG1 calcium channel, voltage-dependent, gamma subunit 1".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.