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Brain-specific angiogenesis inhibitor 3

Available structures
PDBOrtholog search: PDBe RCSB
AliasesADGRB3, BAI3, adhesion G protein-coupled receptor B3
External IDsOMIM: 602684 MGI: 2441837 HomoloGene: 1289 GeneCards: ADGRB3
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for ADGRB3
Genomic location for ADGRB3
Band6q12-q13Start68,635,282 bp[1]
End69,389,506 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 6: 68.64 – 69.39 MbChr 1: 25.07 – 25.83 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.[5][6]

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.[6] }}

The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.[7] BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135298 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033569 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenet Cell Genet. 79 (1–2): 103–8. doi:10.1159/000134693. PMID 9533023.
  6. ^ a b "Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3".
  7. ^ Marc F. Bolliger, David C. Martinelli, and Thomas C. Südhof. The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. PNAS 2011 ; published ahead of print January 24, 2011, doi:10.1073/pnas.1019577108

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.