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Bombesin-like receptor 3

AliasesBRS3, BB3, bombesin like receptor 3, BB3R, bombesin receptor subtype 3, BBR3
External IDsOMIM: 300107 MGI: 1100501 HomoloGene: 1307 GeneCards: BRS3
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for BRS3
Genomic location for BRS3
BandXq26.3Start136,487,947 bp[1]
End136,493,780 bp[1]
RNA expression pattern
PBB GE BRS3 207369 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr X: 136.49 – 136.49 MbChr X: 57.04 – 57.05 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

The bombesin receptor subtype 3 also known as BRS-3 or BB3[5] is a protein which in humans is encoded by the BRS3 gene.[6][7]


Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article).[7][8]

BB3 is a G protein-coupled receptor.[6] BB3 only interacts with known naturally occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor.[6][9][10]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102239 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031130 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Bombesin Receptors: BB3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
  6. ^ a b c Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (March 1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells". J. Biol. Chem. 268 (8): 5979–84. PMID 8383682.
  7. ^ a b Ohki-Hamazaki H, Wada E, Matsui K, Wada K (July 1997). "Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse". Brain Res. 762 (1–2): 165–72. doi:10.1016/S0006-8993(97)00380-6. PMID 9262170.
  8. ^ "Entrez Gene: BRS3 bombesin-like receptor 3".
  9. ^ Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH, Jensen RT (1997). "Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors". J. Biol. Chem. 272 (41): 26062–26071. doi:10.1074/jbc.272.41.26062. PMID 9325344.
  10. ^ Jensen RT, Battey JF, Spindel ER, Benya RV (2007). "International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states". Pharmacol. Rev. 60 (1): 1–42. doi:10.1124/pr.107.07108. PMC 2517428. PMID 18055507.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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