|Trade names||Pfizerpen, other|
|Other names||penicillin G potassium, penicillin G sodium|
|AHFS/Drugs.com||International Drug Names|
|Protein binding||60 %|
|Elimination half-life||30 min|
|E number||E705 (antibiotics)|
|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||334.4 g/mol g·mol−1|
|3D model (JSmol)|
|(what is this?)|
Benzylpenicillin, also known as penicillin G, is an antibiotic used to treat a number of bacterial infections. This includes pneumonia, strep throat, syphilis, necrotizing enterocolitis, diphtheria, gas gangrene, leptospirosis, cellulitis, and tetanus. It is not a first-line agent for pneumococcal meningitis. Benzylpenicillin is given by injection into a vein or muscle. Two long-acting forms benzathine benzylpenicillin and procaine benzylpenicillin are available for use by injection into a muscle.
Side effects include diarrhea, seizures, and allergic reactions including anaphylaxis. When used to treat syphilis a reaction known as Jarisch–Herxheimer may occur. It is not recommended in those with a history of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications.
Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200.
As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as Neisseria gonorrhoeae and Leptospira weilii are also reported to be susceptible to benzylpenicillin.
Adverse effects can include hypersensitivity reactions including urticaria, fever, joint pains, rashes, angioedema, anaphylaxis, serum sickness-like reaction. Rarely CNS toxicity including convulsions (especially with high doses or in severe renal impairment), interstitial nephritis, haemolytic anaemia, leucopenia, thrombocytopenia, and coagulation disorders. Also reported diarrhoea (including antibiotic-associated colitis).
Benzylpenicillin serum concentrations can be monitored either by traditional microbiological assay or by more modern chromatographic techniques. Such measurements can be useful to avoid central nervous system toxicity in any person receiving large doses of the drug on a chronic basis, but they are especially relevant to patients with kidney failure, who may accumulate the drug due to reduced urinary excretion rates.
The production of benzylpenicillin involves fermentation, recovery and purification of the penicillin.
The fermentation process of the production of benzylpencillin is about obtaining the product. The presence of the product in solution inhibits the reaction and reduces the product rate and yield. Thus, in order to obtain the most product and increase the rate of reaction the product, would be continuously extracted out. This is done by having the mold with either glucose, sucrose, lactose, startch, or detrin, nitrate, ammonium salt, corn steep liquor, peptone, meat or yeast extract, and little amounts of inorganic salts.
The recovery of the benzylpencillin is the most important part of the production process because it affects the purification steps if done wrong. There are many different types of techniques to recover benzyl penicillin, aqueous two-phase extraction, liquid membrane extraction, microfiltration technique, and solvent subulation Extraction is more commonly used in the recovery process.[medical citation needed]
The purification step is where benzylpencillin is separated out of the solution that it was in for the extraction. The way that this is done is normally with a separation column.