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PubChem CID
Chemical and physical data
Molar mass4043.727 g·mol−1
3D model (JSmol)

Astressin-B (AST) is a nonselective corticotropin releasing hormone antagonist that reduces the synthesis of ACTH and cortisol.[1]

Reducing ACTH synthesis, it improves the sexual drive of rats under stressing conditions.[2]

In 2011, research showed that treatment with astressin-B caused the sudden growth of hair in mice bred for a propensity for stress.[3]


  1. ^ Vulliémoz NR, Xiao E, Xia-Zhang L, Rivier J, Ferin M (March 2008). "Astressin B, a nonselective corticotropin-releasing hormone receptor antagonist, prevents the inhibitory effect of ghrelin on luteinizing hormone pulse frequency in the ovariectomized rhesus monkey". Endocrinology. 149 (3): 869–74. doi:10.1210/en.2007-1350. PMC 2275354. PMID 18063681.
  2. ^ Miwa Y, Nagase K, Oyama N, Akino H, Yokoyama O (March 2011). "Effect of corticotropin-releasing factor receptor antagonist on psychologically suppressed masculine sexual behavior in rats". J Sex Med. 8 (3): 688–95. doi:10.1111/j.1743-6109.2010.02055.x. PMID 20946165.
  3. ^ Wang, L.; Million, M.; Rivier, J.; Rivier, C.; Craft, N.; Stenzel-Poore, M. P.; Taché, Y. (2011). Polymenis, Michael (ed.). "CRF Receptor Antagonist Astressin-B Reverses and Prevents Alopecia in CRF Over-Expressing Mice". PLoS ONE. 6: e16377. doi:10.1371/journal.pone.0016377. PMC 3040186. PMID 21359208.