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Arbaclofen placarbil

Arbaclofen placarbil
Arbaclofen placarbil.svg
Clinical data
Pregnancy
category
  • N/A
ATC code
  • none
Legal status
Legal status
  • Development terminated
Identifiers
CAS Number
PubChem CID
ChemSpider
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.221.150 Edit this at Wikidata
Chemical and physical data
FormulaC19H26ClNO6
Molar mass399.86 g/mol g·mol−1
3D model (JSmol)

Arbaclofen placarbil (/ɑːrˈbæklfɛn pləˈkɑːrbɪl/ ar-BAK-loh-fen plə-KAR-bil, also known as XP19986) is a prodrug of R-baclofen. Arbaclofen placarbil possesses more favorable pharmacokinetic profile than baclofen, with less fluctuations in plasma drug levels. It was being developed as a potential treatment for patients with GERD and spasticity due to multiple sclerosis; however, in May 2013 XenoPort announced the termination of development because of unsuccessful results in phase III clinical trials.[1]

It is being developed as an addiction medicine to treat alcoholism. [2]

See also

References

  1. ^ "Archived copy". Archived from the original on 2013-12-02. Retrieved 2013-06-03.CS1 maint: archived copy as title (link)
  2. ^ [inews.co.uk]