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Aquaporin 3

AliasesAQP3, AQP-3, GIL, aquaporin 3 (Gill blood group)
External IDsOMIM: 600170 MGI: 1333777 HomoloGene: 21025 GeneCards: AQP3
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for AQP3
Genomic location for AQP3
Band9p13.3Start33,441,156 bp[1]
End33,447,596 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 9: 33.44 – 33.45 MbChr 4: 41.09 – 41.1 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Aquaporin 3 is found in the basolateral cell membrane of principal collecting duct cells and provides a pathway for water to exit these cells.[5] In the kidney, AQP3 is regulated by vasopressin (ADH).[6] This protein is also a determinant for the GIL blood group system.[7]

Suberoylanilide hydroxamic acid (SAHA) (a HDAC inhibitor) increases expression of aquaporin-3 in normal skin cells (keratinocytes).[8]

Clinical significance

AQP3 levels are often lower in psoriasis than in healthy skin.[8]

AQP3 is expressed more in atopic eczema.[9]

See also


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165272 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028435 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sasaki S, Ishibashi K, Marumo F (1998). "Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family colocalized in the kidney collecting duct". Annu. Rev. Physiol. 60: 199–220. doi:10.1146/annurev.physiol.60.1.199. PMID 9558461.
  6. ^ Baynes JW, Dominiczak MH (2014). "Medical Biochemistry". Medical Biochemistry (Textbook) (4 ed.): 346 – via Elsevier.
  7. ^ Roudier N, Ripoche P, Gane P, Le Pennec PY, Daniels G, Cartron JP, Bailly P (2002). "AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL". J. Biol. Chem. 277 (48): 45854–9. doi:10.1074/jbc.M208999200. PMID 12239222.
  8. ^ a b Cancer therapy shows promise for psoriasis treatment
  9. ^ Olsson M, Broberg A, Jernãs M, et al. (2006). "Increased expression of aquaporin 3 in atopic eczema". Allergy. 61 (9): 1132–7. doi:10.1111/j.1398-9995.2006.01151.x. PMID 16918518.

Further reading

External links