To distinguish this city from the many others called Apamea, the name Apamea Myrlea used here adds to the name (Apamea) it was given when rebuilt as an important city the name (Myrlea) it previously bore as a smaller town. It was also referred to as Apamea Myrlēon (Apamea of Myrlea).
The town was founded as a colony of the Colophonians and was called Μύρλεια (Myrleia or Myrlea). Philip V of Macedon took the town, as it appears, during his war against the king of Pergamon, and gave it to his ally, King Prusias I of Bithynia, who fortified and enlarged it – indeed almost rebuilt it – around 202 BC, renaming it Ἀπάμεια (transcribed as Apameia, Apamea, or Apamia), after his wife, Apama III.
Erdek Gulf today
The place was on the south coast of the Gulf of Erdek, and northwest of Bursa, then called Prusa, for which it served as a port.
The Romans made Apamea a colonia, apparently in the time of Augustus, or perhaps Julius Caesar, in view of the adjective "Iulia" that appear on its coins under Roman rule. Its earlier coins were stamped Ἀπαμέων Μυρλεάνων, but in Roman times they bore the label C.I.C.A. (= Colonia Iulia Concordia Apamea).