An Italian multicentre clinical trial on 2,044 patients suffering from recent stroke were supplied alpha-GPC in doses of 1,000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales (Mathew Scale (MS), Mini Mental State Test (MMST), Crichton Rating Scale (CRS) and the Global Deterioration Scale (GDS)) three of which reached statistical significance.[non-primary source needed] In trials utilizing alpha-GPC in vascular dementia, alpha-GPC administation was reported to improve performance on psychometric tests and to be well tolerated by the patient population
Small scale studies focusing on the effects of alpha-GPC on physical performance have also reported that alpa-GPC supplementation can increase maximum power and velocity in specified tests (counter-movement jump test) and increase lower body force (isometric mid-thigh pull test). In iron deficient women, alpa-GPC supplementation has also been reported to enhance non-heme iron uptake from dietary sources.
Industrially, alpha-GPC is produced by the chemical or enzymatic deacylation of phosphatidylcholine enriched soya phospholipids followed by chromatographic purification. Alpha-GPC may also be derived in small amounts from highly purified soy lecithin as well from purified sunflower lecithin.
^De Jesus Moreno Moreno M (January 2003). "Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial". Clinical Therapeutics. 25 (1): 178–93. doi:10.1016/S0149-2918(03)90023-3. PMID12637119.
^ abParnetti L, Mignini F, Tomassoni D, Traini E, Amenta F (June 2007). "Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation?". Journal of the Neurological Sciences. 257 (1–2): 264–9. doi:10.1016/j.jns.2007.01.043. PMID17331541.
^Barbagallo Sangiorgi G, Barbagallo M, Giordano M, Meli M, Panzarasa R (June 1994). "alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks. An Italian multicenter clinical trial". Annals of the New York Academy of Sciences. 717: 253–69. doi:10.1111/j.1749-6632.1994.tb12095.x. PMID8030842.
^Traini, Enea; Bramanti, Vincenzo; Amenta, Francesco (December 2013). "Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipid with a still interesting profile as cognition enhancing agent". Current Alzheimer Research. 10 (10): 1070–1079. doi:10.2174/15672050113106660173. ISSN1875-5828. PMID24156263.
^Di Perri, R.; Coppola, G.; Ambrosio, L. A.; Grasso, A.; Puca, F. M.; Rizzo, M. (July 1991). "A multicentre trial to evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia". The Journal of International Medical Research. 19 (4): 330–341. doi:10.1177/030006059101900406. ISSN0300-0605. PMID1916007.
^Armah, Charlotte N.; Sharp, Paul; Mellon, Fred A.; Pariagh, Sandra; Lund, Elizabeth K.; Dainty, Jack R.; Teucher, Birgit; Fairweather-Tait, Susan J. (May 2008). "L-alpha-glycerophosphocholine contributes to meat's enhancement of nonheme iron absorption". The Journal of Nutrition. 138 (5): 873–877. doi:10.1093/jn/138.5.873. ISSN1541-6100. PMID18424594.