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Other names
3D model (JSmol)
Molar mass 382.460 g·mol−1
Melting point 225 °C (437 °F; 498 K)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Akuammine (vincamajoridine[2]) is an indole alkaloid. It is the most abundant alkaloid found in the seeds from the tree Picralima nitida,[3] commonly known as akuamma, comprising 0.56% of the dried powder. It has also been isolated from Vinca major.[2] Akuammine is structurally related to both yohimbine and mitragynine, both of which are alkaloid plant products with pharmacological properties.


Akuammine has antimalarial activity,[3] and may be the primary constituent of P. nitida seeds responsible for this activity.[4]

Akuammine is an opioid antagonist with low affinity, selective for the mu-opioid receptor, when tested in vitro.[5][6]


  1. ^ Merck Index (12th ed.). 200.
  2. ^ a b Janot, M. M.; Le Men, J.; Aghoramurthy, K.; Robinson, R. (1955). "The identity of vincamajoridine and akuammine". Experientia. 11 (9): 343. doi:10.1007/BF02159911.
  3. ^ a b Kapadia, G. J.; Angerhofer, C. K.; Ansa-Asamoah, R (1993). "Akuammine: An antimalarial indolemonoterpene alkaloid of Picralima nitida seeds". Planta Medica. 59 (6): 565–6. doi:10.1055/s-2006-959764. PMID 8302957.
  4. ^ Hans Dieter Neuwinger (1996). African Ethnobotany: Poisons and Drugs : Chemistry, Pharmacology, Toxicology. CRC Press. p. 123. ISBN 9783826100772.
  5. ^ Menzies, J. R.; Paterson, S. J.; Duwiejua, M; Corbett, A. D. (1998). "Opioid activity of alkaloids extracted from Picralima nitida (fam. Apocynaceae)". European Journal of Pharmacology. 350 (1): 101–8. doi:10.1016/s0014-2999(98)00232-5. PMID 9683021.
  6. ^ Lewin, G; Le Ménez, P; Rolland, Y; Renouard, A; Giesen-Crouse, E (1992). "Akuammine and dihydroakuammine, two indolomonoterpene alkaloids displaying affinity for opioid receptors". Journal of Natural Products. 55 (3): 380–4. doi:10.1021/np50081a017. PMID 1317407.
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