This page uses content from Wikipedia and is licensed under CC BY-SA.


3D model (JSmol)
Molar mass 322.408 g·mol−1
Appearance White solid[1]
Melting point 182 °C (360 °F; 455 K)[2]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Akuammicine is an alkaloid found in Vinca minor and Aspidosperma.[3] It is a μ-opioid receptor agonists while also agonizing (but to a much lower, clinically insignificant degree) the κ and δ-opioid receptors. Agonistic activity at both human variants of the σ-sigma receptors has been indicated but is not yet proven, so have possible mechanisms of action at the NMDA receptor (antagonist) and glycine receptor.


  1. ^ Shittu, Hafsat; Gray, Alexander; Furman, Brian; Young, Louise (2010). "Glucose uptake stimulatory effect of akuammicine from Picralima nitida (Apocynaceae)". Phytochemistry Letters. 3 (1): 53–55. doi:10.1016/j.phytol.2009.11.003. ISSN 1874-3900.
  2. ^ Robinson, Robert; Thomas, A. F. (1955). "The Alkaloids of Picralima nitida, Stapf, Th. and H. Durand. Part III. A Note on Akuammicine and pseudoAkuammicine". Journal of the Chemical Society (Resumed): 2049. doi:10.1039/jr9550002038. ISSN 0368-1769.
  3. ^ Mitaine, A. C.; Mesbah, K; Richard, B; Petermann, C; Arrazola, S; Moretti, C; Zèches-Hanrot, M; Men-Olivier, L. L. (1996). "Alkaloids from Aspidosperma species from Bolivia". Planta Medica. 62 (5): 458–61. doi:10.1055/s-2006-957939. PMID 17252481.