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Clinical data
Trade namesAlizine
Other namesRU-46534; RU-534; 11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17α-[(Z)-propenyl]estra-4,9-dien-3-one
Drug classAntiprogestogen; Antiglucocorticoid
ATC code
CAS Number
PubChem CID
ECHA InfoCard100.211.372 Edit this at Wikidata
Chemical and physical data
Molar mass431.62 g/mol g·mol−1
3D model (JSmol)

Aglepristone (INN) (brand name Alizine; former developmental code names RU-46534, RU-534) is a synthetic, steroidal antiprogestogen related to mifepristone which is marketed by Virbac in several European countries for use in veterinary medicine.[1][2][3] It is specifically used as an abortifacient in pregnant animals.[1][3][4] Aglepristone, similarly to mifepristone, also possesses some antiglucocorticoid activity.[5][6]

See also


  1. ^ a b John D. Bonagura; David C. Twedt (1 December 2013). Kirk's Current Veterinary Therapy XV. Elsevier Health Sciences. pp. 3009–. ISBN 978-0-323-22762-9.
  2. ^ E. James Squires (2010). Applied Animal Endocrinology. CABI. pp. 207–. ISBN 978-1-84593-755-3.
  3. ^ a b Mark G. Papich (3 November 2010). Saunders Handbook of Veterinary Drugs: Small and Large Animal. Elsevier Health Sciences. pp. 120–. ISBN 1-4377-0192-2.
  4. ^ Patrick W. Concannon (2001). Advances in reproduction in dogs, cats and exotic carnivores: proceedings of the fourth International Symposium on Canine and Feline Reproduction, Oslo, Norway, 29 June-1 July 2000. Journal of Reproduction and Fertility. ISBN 978-0-906545-37-9.
  5. ^ Batista M, Reyes R, Santana M, Alamo D, Vilar J, González F, Cabrera F, Gracia A (2011). "Induction of parturition with aglepristone in the Majorera goat". Reprod. Domest. Anim. 46 (5): 882–8. doi:10.1111/j.1439-0531.2011.01759.x. PMID 21320179.
  6. ^ Baan M, Taverne MA, de Gier J, Kooistra HS, Kindahl H, Dieleman SJ, Okkens AC (2008). "Hormonal changes in spontaneous and aglépristone-induced parturition in dogs". Theriogenology. 69 (4): 399–407. doi:10.1016/j.theriogenology.2007.10.008. PMID 18054071.