|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||189.30 g/mol g·mol−1|
AC927 or 1-(2-phenylethyl)piperidine is a selective sigma receptor antagonist, with reported binding affinity of Ki = 30 ± 2 nM for the sigma-1 receptor and Ki = 138 ± 18 nM for the sigma-2 receptor, and negligible binding affinity for other major central nervous system receptors, transporters, and ion channels.
AC927 is reported to attenuate the locomotor stimulation induced by methamphetamine in mice.