A-372159 is a drug which acts as a potent and selective partial agonist for the 5HT2Creceptor, with more than 100x selectivity over the closely related 5-HT2B receptor and a Ki of 3nM. It has been found to produce anorectic effects in animal studies and produced significant weight loss in rats with no development of tolerance or serious side effects.
^Childers WE, Robichaud AJ. Recent Advances in Selective Serotonergic Agents. Annual Reports in Medicinal Chemistry 2005; Volume 40:17-33. ISBN978-0-12-040540-4