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CAS Number
PubChem CID
Chemical and physical data
Molar mass403.470 g/mol g·mol−1
3D model (JSmol)
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7-Spiroindanyloxymorphone (SIOM) is a drug that is used in scientific research. It is a selective δ-opioid agonist. It is a derivative of oxymorphone.[1][2][3][4][5]


  1. ^ Portoghese, PS; Moe, ST; Takemori, AE (1993). "A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists". Journal of Medicinal Chemistry. 36 (17): 2572–4. doi:10.1021/jm00069a017. PMID 8394935.
  2. ^ Fang, X; Larson, DL; Portoghese, PS (1997). "7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands". Journal of Medicinal Chemistry. 40 (19): 3064–70. doi:10.1021/jm970283e. PMID 9301669.
  3. ^ Ohkawa, S; Digiacomo, B; Larson, DL; Takemori, AE; Portoghese, PS (1997). "7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors". Journal of Medicinal Chemistry. 40 (11): 1720–5. doi:10.1021/jm9700880. PMID 9171881.
  4. ^ Kshirsagar, TA; Fang, X; Portoghese, PS (1998). "14-Desoxy analogues of naltrindole and 7-spiroindanyloxymorphone: the role of the 14-hydroxy group at delta opioid receptors". Journal of Medicinal Chemistry. 41 (14): 2657–60. doi:10.1021/jm980209b. PMID 9651172.
  5. ^ Shenderovich, MD; Liao, S; Qian, X; Hruby, VJ (2000). "A three-dimensional model of the delta-opioid pharmacophore: comparative molecular modeling of peptide and nonpeptide ligands". Biopolymers. 53 (7): 565–80. doi:10.1002/(SICI)1097-0282(200006)53:7<565::AID-BIP4>3.0.CO;2-5. PMID 10766952.