4,4'-Dimethylaminorex Clinical data Other names 4,4'-DMAR ATC code Legal status Legal status
: DE Anlage II (Authorized trade only, not prescriptible)
UK: Class A Illegal in Czech Republic and Sweden Identifiers
4-Methyl-5-(4-methylphenyl)-4,5-dihydro-1,3-oxazol-2-amine CAS Number PubChem CID ChemSpider UNII Chemical and physical data Formula C 11 H 14 N 2 O Molar mass g·mol 190.246 −1 3D model ( JSmol)
4,4'-Dimethylaminorex (abbreviated as 4,4'-DMAR), sometimes referred to by the street name "Serotoni", is a psychostimulant and entactogen designer drug related to aminorex, 4-methylaminorex, and pemoline. It was first detected in the Netherlands in December 2012,  and has been sold as a  designer drug around Europe since mid-2013.
4,4'-DMAR had been linked to at least 31 deaths in Hungary, Poland, and the UK by February 2014, mostly when consumed in combination with other drugs.
Nineteen deaths linked to 4,4'-DMAR were reported in Northern Ireland in the same time period. 
4,4'-DMAR acts as a potent and balanced
serotonin-norepinephrine-dopamine releasing agent (SNDRA), with EC values for 50 serotonin, norepinephrine, and dopamine release of 18.5 nM, 26.9 nM, and 8.6 nM, respectively.
The UK Home Office expressed intent to ban 4,4'-DMAR following advice from the
Advisory Council on the Misuse of Drugs and subsequently it became a class A drug on 11 March 2015. 
4,4'-DMAR is an
Anlage II controlled substance in Germany as of May 2015 .
Sweden's public health agency suggested to classify 4,4'-DMAR as hazardous substance on November 10, 2014.
4,4'-DMAR is also banned in the Czech Republic.
^ a b
Brandt, Simon D.; Baumann, Michael H.; Partilla, John S.; Kavanagh, Pierce V.; Power, John D.; Talbot, Brian; Twamley, Brendan; Mahony, Olivia; O'Brien, John; Elliott, Simon P.; Archer, Roland P.; Patrick, Julian; Singh, Kuldip; Dempster, Nicola M.; Cosbey, Simon H. (2014). "Characterization of a novel and potentially lethal designer drug(±)-cis-para-methyl-4-methylaminorex (4,4'-DMAR, or 'Serotoni')". Drug Testing and Analysis. 6 (7–8): 684–695. doi: 10.1002/dta.1668. ISSN 1942-7603. PMC . 4128571 PMID 24841869.
EMCDDA 2012 Annual report on the state of the drugs problem in Europe
"Risk Assessment Report of a new psychoactive substance: 4-methyl-5-(4-methylphenyl)-4,5-dihydrooxazol-2-amine (4,4′-dimethylaminorex, 4,4′-DMAR)" (PDF). European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). November 2014.
Unregulated stimulant drug blamed for 19 deaths, Belfast inquest told. The Guardian, Thursday 5 June 2014
"Letter to ACMD regarding advice on MT-45 and 4,4'-DMAR". UK Home Office. 26 November 2014 . Retrieved . 19 February 2015
"Circular 003/2015: a change to the Misuse of Drugs Act 1971: control of MT-45 and 4,4'-DMAR". UK Home Office. 20 February 2015 . Retrieved . 11 March 2015
"Gesetz über den Verkehr mit Betäubungsmitteln (Betäubungsmittelgesetz - BtMG) Anlage II (zu § 1 Abs. 1) (verkehrsfähige, aber nicht verschreibungsfähige Betäubungsmittel)" (in German) . Retrieved . 29 June 2015
"Cannabinoider föreslås bli klassade som hälsofarlig vara" (in Swedish) . Retrieved . 29 June 2015
"Látky, o které byl doplněn seznam č. 4 psychotropních látek (příloha č. 4 k nařízení vlády č. 463/2013 Sb.)" (PDF) (in Czech). Ministerstvo zdravotnictví.