Evaluation of its metabolic pathway revealed N‐oxidation, aryl hydroxylation and subsequent O‐methylation, alkyl hydroxylation, oxidation, and degradation of the ethyl‐bridge yielding the O/N‐bis‐dealkylated metabolite, combinations thereof and further glucuronidation or sulfations.
In the United States, 3-fluorophenmetrazine is not explicitly illegal at the federal level. However, on November 16, 2016, it became an illegal substance in the state of Virginia. Pursuant to subsection D of § 54.1-3443 of the Code of Virginia, the state Board of Pharmacy designated it as a Schedule I controlled substance, effective through May 10, 2018. Although the initial regulatory period has lapsed, during their 2019 legislative session, the Virigina state legislature is set to vote on a bill that would permanently schedule 3-fluorophenmetrazine as an illegal, Schedule I substance, and it is likely that the bill will succeed. 
Sweden's public health agency suggested to classify 3-Fluorophenmetrazine as illegal narcotic on June 1, 2015. It was finally classified on October 15, 2015.
3-Fluorophenmetrazine is illegal in Switzerland as of December 2015.
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