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2-Thiouracil

2-Thiouracil
2-Thiouracil.png
Names
IUPAC name
2-Thioxo-1H-pyrimidin-4-one
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.005.008
KEGG
MeSH Thiouracil
UNII
Properties
C4H4N2OS
Molar mass 128.15 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

2-Thiouracil is a specific molecule consisting of a sulfated uracil.

Medical use

The substance is a historically relevant anti-thyroid preparation. Astwood E.B. used it in 1943 as therapy of Graves' disease for the first time.[1] It remains in use.

Thiouracil inhibits thyroid activity by blocking the enzyme thyroid peroxidase.[2] Its use in recent times has been replaced by advent of more potent and safer antithyroid drugs.

References

  1. ^ Gerabek, W. (2005). Enzyklopädie Medizingeschichte. p. 152. ISBN 978-3-11-015714-7.
  2. ^ Nagasaka, A.; Hidaka, H. (1976). "Effect of Antithyroid Agents 6-Propyl-2-Thiouracil and l-Methyl-2-Mercaptoimidazole on Human Thyroid Iodide Peroxidase". Journal of Clinical Endocrinology & Metabolism. 43 (1): 152–8. doi:10.1210/jcem-43-1-152. PMID 947933.