1P-LSD Legal status Legal status
(6a R,9 R)- N, N-Diethyl-7-methyl-4-propanoyl-6,6a,8,9-tetrahydroindolo[4,3- fg]quinoline-9-carboxamide CAS Number PubChem CID ChemSpider UNII Chemical and physical data Formula C 23 H 29 N 3 O 2 Molar mass g·mol 379.504 −1 3D model ( JSmol)
1P-LSD or 1-propionyl-lysergic acid diethylamide is a psychedelic drug of the lysergamide class that is a derivative and functional analogue of LSD and a homologue of ALD-52. It has been sold online as a designer drug since 2015.      It modifies the LSD molecule by adding a  propionyl group to the nitrogen molecule of LSD's indole.
In mice, 1P-LSD produces LSD-like effects with 38% the potency of LSD and it is therefore classed as a
serotonergic hallucinogen. However, 1P-LSD itself is unable to bind to the serotenergic  5-HT. 2A receptors  But since LSD is detected when 1P-LSD is incubated in human serum,  1P-LSD may act, at least in part, as a  prodrug for LSD.
1P-LSD on blotter paper
The effects profile of 1P-LSD is not well defined in the scientific literature. It is generally thought to be comparable to that of LSD.
Many anecdotal reports indicate that 1P-LSD has a slightly shorter duration than LSD in humans, with the majority of users stating that they cannot distinguish the qualitative effects of 1P-LSD from LSD.
1P-LSD is illegal in Denmark.
1P-LSD is illegal in Finland.
1P-LSD is illegal in Germany as part of the NpSG.
1P-LSD is illegal in Estonia since 4 June 2017.
1P-LSD is illegal in Japan since 18 April 2016.
1P-LSD is illegal in Latvia. Although it isn't specifically scheduled, it is controlled as an LSD structural analog due to an amendment made on June 1, 2015.
1P-LSD is illegal in Lithuania.
1P-LSD is illegal in Norway.
1P-LSD is illegal to produce or sell in Romania. It is not included directly in the list of controlled substances, but it is included in
an analogue act. However, it is not, as of yet, classified as illegal to use.
Public Health Agency of Sweden added 1P-LSD as health hazard under the act Act on the Prohibition of Certain Goods Dangerous to Health ( ) in Sweden as of January 26, 2016, published in SFS 1999:42 SFS 2015:997 listed as N,N-dietyl-6-metyl-1-propionyl-9,10-didehydroergolin-8-karboxamid (1P-LSD).
1P-LSD is illegal in Switzerland.
Although not explicitly listed under the
Misuse of Drugs Act 1971, 1P-LSD may be covered in the UK under the Psychoactive Substances Act.
While 1P-LSD is not
controlled at the federal level in the United States, it is possible that 1P-LSD could be considered as an analogue of LSD, in which case trade or possession with intent for human consumption could be prosecuted under the Federal Analogue Act.
1P-LSD is illegal in Czech Republic since 8 March 2018.
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Brandt SD, Kavanagh PV, Westphal F, Stratford A, Elliott SP, Hoang K, et al. (September 2016). "Return of the lysergamides. Part I: Analytical and behavioural characterization of 1-propionyl-d-lysergic acid diethylamide (1P-LSD)". Drug Testing and Analysis. 8 (9): 891–902. doi: 10.1002/dta.1884. PMC . 4829483 PMID 26456305.
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