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1615 ( MDCXV) was a common year starting on Thursday of the Gregorian calendar and a common year starting on Sunday of the Julian calendar, the 1615th year of the Common Era (CE) and (AD) designations, the 615th year of the Anno Domini 2nd millennium, the 15th year of the 17th century, and the 6th year of the 1610s decade. As of the start of 1615, the Gregorian calendar was 10 days ahead of the Julian calendar, which remained in localized use until 1923.
January 1 – The New Netherland Company is granted a three-year monopoly in North American trade, between the 40th and 45th parallels.
February – Sir Thomas Roe sets out to become the first ambassador from the court of the King of England to the Mughal Emperor Jahangir,  sailing in the  Lyon under the command of captain Christopher Newport.
March 10 – John Ogilvie, a Jesuit priest, is hanged and drawn at Glasgow Cross in Scotland for refusing to pledge allegiance to King James VI of Scotland; he will be canonised in 1976, becoming the only post- Reformation Scottish saint.
April 21 – The Wignacourt Aqueduct is inaugurated in Malta.
May 6 – The Peace of Tyrnau is signed between Matthias, Holy Roman Emperor, and Gábor Bethlen.
June 2 – The first Récollet missionaries arrive at Quebec City, from Rouen, France.
June 3 – The Eastern Army of Tokugawa Ieyasu and the Osaka Army of Toyotomi Hideyori clash during the Battle of Dōmyōji and the Battle of Tennōji.
June 4 – Forces under shōgun Tokugawa Ieyasu take Osaka Castle in Japan, beginning a period of peace which lasts nearly 250 years. Bands of Christian samurai support Ieyasu's enemies at the Battle of Osaka. June 21 – The Peace of Asti is concluded between the Spanish Empire and Savoy. 
Easter – Persian
Safavid hordes led by Shah Abbas the Great kill all the monks at the David Gareja monastery complex in Georgia and set fire to its collection of manuscripts and works of art.
Mary Talbot, Countess of Shrewsbury, is released from the Tower of London, in recognition of her role in helping to discover the murder of Sir Thomas Overbury. The
Somers Isles Company is founded to administer Bermuda.
John Browne is created the first King's Gunfounder in England. Austrian merchants receive economic privileges in the
The Perse School in Cambridge, England, is founded by Dr Stephen Perse.
Wilson's School in Wallington, near London, is founded by Royal Charter. The
Grolsch Brewery is founded in Groenlo, Netherlands. Konoike Shinroku opens an office in
Osaka, and begins shipping tax-rice from western Japan to Osaka.
Johannes Kepler publishes Dissertatio cum Nuncio Sidereo, in response to Galileo's discovery of Jupiter's moons.
Manuel Dias, a Portuguese Jesuit missionary, introduces for the first time in China the telescope, in his book Tian Wen Lüe ( Explicatio Sphaerae Coelestis). The second volume of Miguel de Cervantes's is published, and is as successful as the first. Don Quixote ("El ingenioso hidalgo Don Quijote de la Mancha") Don Quixote eventually becomes the only truly famous work its author ever writes.
January 6 – Richard Waldron, colonial settler, acting President of the Province of New Hampshire (d. 1689)
January 10 – Sir John Robinson, 1st Baronet, of London, English politician (d. 1680)
January 13 – Henrik Bjelke, Norwegian military officer (d. 1683)
January 14 – John Biddle, English theologian (d. 1662)
January 20 – Karmabai, Indian Jat known as Bhakt Shiromani Karmabai (d. 1634)
January 25 – Govert Flinck, Dutch painter of the Dutch Golden Age (d. 1660)
January 27 – Nicolas Fouquet, French Superintendent of Finances (d. 1680)
January 30 – Thomas Rolfe, only child of Pocahontas and her English husband (d. 1675)
February 18 – Maria Caterina Farnese, Duchess of Modena and Reggio (d. 1646)
February 27 – Isaac Thornton, English politician (d. 1669)
March 10 – Hans Ulrik Gyldenløve, illegitimate son of King Christian IV of Denmark and his mistress (d. 1645)
March 11 – Johann Weikhard of Auersperg, Austrian prime minister (d. 1677)
March 13 – Pope Innocent XII (d. 1700)
March 17 – Gregorio Carafa, Grandmaster of the Order of Saint John (d. 1690)
March 20 – Dara Shikoh, Indian prince (d. 1659)
March 22 – Katherine Jones, Viscountess Ranelagh, English female scientist (d. 1691)
March 28 – Pieter de Groot, Dutch diplomat (d. 1678) March 28 – Cosimo Ruggeri, Italian astrologer
July 1 – Samuel Hales, Connecticut settler and politician (d. 1693)
July 9 – Sir Thomas Sclater, 1st Baronet, English politician (d. 1684)
July 22 – Marguerite of Lorraine, princess of Lorraine, duchess of Orléans (d. 1672)
July 28 – Charles de Noyelle, French Jesuit Superior General (d. 1686)
August 13 – John Sherburne, American colonial (d. 1693)
August 15 – Marie de Lorraine, Duchess of Guise (d. 1688)
August 18 – John Sadler, British town clerk (d. 1674)
September 3 – Mary Bradbury, accused Salem, Massachusetts witch (d. 1700)
September 7 – John Birch, English politician (d. 1691)
September 17 – Nicholas Pedley, English politician (d. 1685)
September 20 – Giambattista Spinola, Italo-Spanish Roman Catholic cardinal (d. 1704) September 26 – Heinrich Bach, German organist and composer (d. 1692)
October 1 – Hugh Bethell, English Member of Parliament and High Sheriff (d. 1679)
October 8 – Erdmann August of Brandenburg-Bayreuth, Hereditary Margrave (d. 1651)
October 23 – Ove Juul, Governor-General of Norway (d. 1686)
October 27 – Christian I, Duke of Saxe-Merseburg, member of the House of Wettin (d. 1691)
November 5 – Ibrahim, Ottoman Sultan (d. 1648)
November 12 – Richard Baxter, English Puritan church leader (d. 1691)
November 19 – Richard Norton of Southwick Park, English politician (d. 1691)
November 20 – Francis Dane, American colonial priest (d. 1697)
November 24 – Philip William, Elector Palatine (d. 1690)
December 6 – Frederick Schomberg, 1st Duke of Schomberg (d. 1690)
December 7 – Nicodemus Tessin the Elder, Swedish architect (d. 1681)
December 9 – Anne Carr, Countess of Bedford, English noble (d. 1684)
December 19 – Frederick, Duke of Württemberg-Neuenstadt, German duke (d. 1682)
December 21 – Benedict Arnold, Rhode Island colonial governor (d. 1678)
December 29 – Charles Scarborough, English physician, mathematician (d. 1694) Date unknown:
January 15 – Virginia de' Medici, Italian princess (b. 1568)
January 16 – Roger Fenton, English clergyman (b. 1565)
January 31 – Claudio Acquaviva, Italian Jesuit priest, elected (in 1581) the 5th Superior General of the Society of Jesus (b. 1543)
February 4 – Giambattista della Porta, Italian scholar, polymath, playwright (b. 1535)
February 3 or February 5 – Dom Justo Takayama, Japanese warlord (b. 1552)
March 4 – Hans von Aachen, German painter (b. 1552)
March 6 – Pieter Both, first Governor-General of the Dutch East Indies (b. 1568)
March 10 – John Ogilvie, Scottish Catholic Jesuit martyr (b. 1579)
March 19 – Henry Pierrepont, English politician (b. 1546) March 27 – Margaret of Valois, Queen of France (b. 1553)
October 9 – Hasan Kafi Pruščak, Bosnian scholar and judge (b. 1544)
October 18 – Cherubino Alberti, Italian engraver and painter (b. 1553)
October 31 – Marcantonio Memmo, Doge of Venice (b. 1536)
November 6 – Sir Richard Musgrave, 1st Baronet, English politician (b. 1585)
November 14 – John Leveson, English politician (b. 1555)
November 15 – Anne Turner, English murderer (b. 1576)
November 20 – Gervase Helwys, English murderer (b. 1561)
November 24 – Sethus Calvisius, German calendar reformer (b. 1556)
November 28 – William Howard, 3rd Baron Howard of Effingham, English politician and Baron (b. 1577)
November 29 – George Albert II, Margrave of Brandenburg (b. 1591) November –
Edward Wright, English mathematician and cartographer (b. 1561)
December 7 – Gerard Reynst, Dutch merchant (b. c. 1558) December 26 – August of Saxony, German prince (b. 1589)