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1460s decade ran from January 1, 1460, to December 31, 1469.
March 5 – King Christian I of Denmark issues the Treaty of Ribe, enabling himself to become Count of Holstein, and regain control of Denmark's lost Duchy of Schleswig.
June 26 – Wars of the Roses: Richard Neville, Earl of Warwick and Edward, Earl of March (eldest son of Richard Plantagenet, Duke of York) land in England with an army, and march on London.
July 4 – The cannons of the Tower of London, still in Lancastrian hands, are fired on the city of London, which is mostly in Yorkist hands. The Tower is surrendered on July 19. 
July 10 – Wars of the Roses – Battle of Northampton: Warwick and March defeat a Lancastrian army and seize King Henry VI of England. It is agreed that York will be Henry's heir, disinheriting the King's son  Edward of Westminster, Prince of Wales.
August 3 – While supervising a siege of English occupiers of Roxburgh Castle, King James II of Scotland is killed, when one of his own cannons explodes.
December 30 – Wars of the Roses – Battle of Wakefield: A Lancastrian army under Henry Beaufort, Duke of Somerset and Henry Percy, Earl of Northumberland decisively defeats a Yorkist army under Richard of York and his son, Edmund, Earl of Rutland, who are both killed (the latter murdered after the battle). York's son Edward becomes leader of the Yorkist faction.
February 2 – Battle of Mortimer's Cross: Yorkist troops led by Edward, Duke of York defeat Lancastrians under Owen Tudor and his son Jasper Tudor, Earl of Pembroke in Wales.
February 17 – Second Battle of St Albans, England: The Earl of Warwick's army is defeated by a Lancastrian force under Queen Margaret, who recovers control for her husband.
March 4 – The Duke of York seizes London, and proclaims himself King Edward IV of England.
March 5 – Wars of the Roses: Henry VI of England is deposed by Edward, Duke of York.
March 29 – Battle of Towton: Edward IV defeats Queen Margaret, to make good his claim to the English throne (thought to be the bloodiest battle ever fought in England).
July 10 – Stephen Tomašević becomes the last King of Bosnia, on the death of his father Stephen Thomas; he is crowned on November 17, in Saint Mary's Church, Jajce.
June 28 – Edward, Richard of York's son, is crowned as Edward IV, King of England (reigns until 1483).
July – Byzantine general Graitzas Palaiologos honourably surrenders Salmeniko Castle, the last garrison of the Despotate of the Morea, to invading forces of the Ottoman Empire, after a year-long siege.
July 22 – Louis XI of France succeeds Charles VII of France as king (reigns until 1483).
August 7 – The Ming Dynasty Chinese military general Cao Qin stages a coup against the Tianshun Emperor; after setting fire to the eastern and western gates of the Imperial City, Beijing (which are doused by pouring rains during the day-long uprising), Cao Qin finds himself hemmed in on all sides by imperial forces, loses three of his own brothers in the fight, and instead of facing execution, he flees to his home in the city, and commits suicide by jumping down a well located within his walled compound.
August 15 – The Empire of Trebizond, the last major Romano-Greek outpost, falls to the Ottoman Empire under Mehmed II, after a 21-day siege.
November 26 – A severe earthquake occurs in L'Aquila.
April 25 – Battle of Hedgeley Moor in England: Yorkist forces under John Neville defeat the Lancastrians under Sir Ralph Percy, who is killed. 
May 1 – Edward IV of England secretly marries Elizabeth Woodville, and keeps the marriage a secret for 5 months afterwards. 
May 15 – Battle of Hexham: Neville defeats another Lancastrian army, this one led by King Henry and Queen Margaret themselves. This marks the end of organized Lancastrian resistance for several years.
June 11 – A 15-year-truce between the kingdoms of England and Scotland is signed. 
June 18 – Pope Pius II himself shoulders the cross of the Crusades, and departs for Ancona to participate in person. He names Skanderbeg general captain of the Holy See, under the title Athleta Christi. This plan forces Skanderbeg to break his 10-year peace treaty with the Ottomans signed in 1463, by attacking their forces near Ohrid.
June 23 – Christian I of Denmark and Norway, who is also serving as King of Sweden, is declared deposed from the latter throne. His deposed predecessor Charles VIII of Sweden is re-elected to the throne on August 9.
August 21 – Emperor Go-Hanazono of Japan abdicates, and is succeeded by his son, Emperor Go-Tsuchimikado.
August 30 – Pope Paul II succeeds Pope Pius II ,as the 211th pope.
China, a small rebellion occurs in the interior province of Huguang, during the Ming Dynasty; a subsequent rebellion springs up in Guangxi, where a rebellion of the Miao people and Yao people forces the Ming throne to respond, by sending 30,000 troops (including 1,000 Mongol cavalry) to aid the 160,000 local troops stationed in the region, to crush the rebellion that will end in 1466.   Jehan Lagadeuc writes a Breton-French-Latin dictionary called the
. It is the first French dictionary as well as the first Breton dictionary of world history, and it will be published in Catholicon 1499.
Tenguella, the founder of the Empire of Great Fulo, becomes chief of the Fula people.
January 24 – The second siege of Chilia by Stephen the Great - the city is conquered.
January 29 – Amadeus IX becomes Duke of Savoy.
January 30 – Charles VIII of Sweden is deposed. Clergyman Kettil Karlsson Vasa becomes Regent of Sweden.
July 13 – Battle of Montlhéry: Troops of King Louis XI of France fight inconclusively against an army of great nobles, organized as the League of the Public Weal.
July 24 – Former King Henry VI of England is captured by Yorkist forces, and imprisoned in the Tower of London. His queen consort Margaret of Anjou and Edward of Westminster, Prince of Wales, have fled to France.
August 11 – In Sweden, Regent Kettil Karlsson Vasa, Bishop of Linköping, dies and is succeeded by Archbishop Jöns Bengtsson Oxenstierna, as Regent.
October 14 – Wallachian voivode Radu cel Frumos, younger brother of Vlad Țepeș, issues a writ from his residence in Bucharest, the earliest known document to mention the city by name.
Third Siege of Krujë: A few months after the failure of the second siege, Mehmed II leads another unsuccessful Ottoman invasion of Albania. The
Ōnin War (1467– 1477), which initiates the Sengoku period in Japan, begins. While
Hassan III of the Maldives is on Hajj, Sayyidh Muhammad deposes his son, acting regent. On his return, Hassan regains the throne. Some papal
abbreviators are arrested and tortured on the orders of Pope Paul II, among them Filippo Buonaccorsi. King
Matthias Corvinus founds the first university in Slovakia, the in Universitas Istropolitana Bratislava. The
polyalphabetic cipher is invented by Leon Battista Alberti (approximate date).
Juan de Torquemada's book, , is published. Meditationes, seu Contemplationes devotissimae 
Charles I (the Bold) (1433–1477), Duke of Burgundy, r. 1467–1477
Jean Fouquet of France (1420–1481), painter
Francis II (1433–1488), Duke of Brittany, r. 1458–1488
Gendun Drup of Tibet (1391–1474), First Dalai Lama
Diogo Gomes of Portugal (1420–1485), navigator, explorer and writer
Johannes Gutenberg of Mainz (1395?–1468), printer and inventor of the movable type printing press
Henry the Navigator of Portugal (1394–1460), Portuguese prince and patron of exploration
William Herbert of Wales (1423–1469), Pro-York nobleman Sir
Thomas Malory of England (1405?–1471), soldier, member of Parliament, political prisoner, and author of Le Morte d'Arthur
Richard Neville of England (1428–1471), nobleman, administrator, and military commander
Demetrios Palaiologos of Morea (1407–1470), Byzantine Prince and Despot of Morea
Thomas Palaiologos of Morea (1409–1465), Byzantine Prince and Despot of Morea
Philip III (the Good) (1396–1467), Duke of Burgundy, r. 1419–1467
Richard Plantagenet, Duke of Gloucester (1452–1483), English Prince, Yorkist commander, and future King of England
Richard Plantagenet, 3rd Duke of York of England (1411-1460), nobleman, military commander, and Yorkist claimant to the Throne of England Mar Shimun IV,
Patriarch of the Assyrian Church of the East (Patriarchate then based in Mosul), held position 1437–1497
Tlacaelel (1397-1487), Tlacochcalcatl of the Aztec empire
Jasper Tudor of Wales (c.1431–1495), nobleman and adventurer
Owen Tudor of Wales (c.1400–1461), soldier and courtier at the court of the English Kings
Andrea del Verrocchio of Florence (1435–1488), painter, sculptor, and goldsmith