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CiteSeerX — Brain activation by disgust-inducing pictures in obsessive-compulsive disorder


Brain activation by disgust-inducing pictures in obsessive-compulsive disorder (2003)


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by Nathan A. Shapira , Yijun Liu , Alex G. He , Margaret M. Bradley , Mary C. Lessig , George A. James , Dan J. Stein , Peter J. Lang , Wayne K. Goodman Venue: Biol. Psychiatry Citations: 19 - 0 self


    author = {Nathan A. Shapira and Yijun Liu and Alex G. He and Margaret M. Bradley and Mary C. Lessig and George A. James and Dan J. Stein and Peter J. Lang and Wayne K. Goodman},
    title = {Brain activation by disgust-inducing pictures in obsessive-compulsive disorder},
    journal = {Biol. Psychiatry},
    year = {2003},
    pages = {751--756}





Background: There is growing interest in the role of disgust in the pathogenesis of obsessive-compulsive disor-der (OCD). Methods: Eight OCD subjects with contamination preoc-cupations and eight gender- and age-matched healthy volunteers viewed pictures from the International Affective Picture System during functional magnetic resonance imaging scans. Results: A different distribution of brain activations was found during disgust-inducing visual stimulation in sev-eral areas, most notably the insula, compared with neutral stimulation in both OCD subjects and healthy volunteers. Furthermore, whereas activation during the threat-induc-ing task in OCD subjects showed a pattern similar to that in healthy volunteers, the pattern of activation during the disgust-inducing task was significantly different, including greater increases in the right insula, parahippocampal region, and inferior frontal sites. Conclusions: This pilot study supports the relevance of disgust in the neurocircuitry of OCD with contamination-preoccupation symptoms; future studies looking at non-OCD individuals with high disgust ratings, non–contam-ination-preoccupied OCD individuals, and individuals with other anxiety disorders are needed. Biol Psychiatry


brain activation    disgust-inducing picture    obsessive-compulsive disorder    healthy volunteer    ocd subject    functional magnetic resonance imaging scan    pilot study    right insula    biol psychiatry    non contam-ination-preoccupied ocd individual    age-matched healthy volunteer    disgust-inducing visual stimulation    obsessive-compulsive disor-der    whereas activation    high disgust rating    eight ocd    contamination-preoccupation symptom    inferior frontal site    threat-induc-ing task    non-ocd individual    parahippocampal region    contamination preoc-cupations    anxiety disorder    sev-eral area    disgust-inducing task    neutral stimulation    international affective picture system    different distribution    future study

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