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Alkaloids of Stipa robusta (sleepygrass) infected with an Acremonium endophyte - Petroski - 2006 - Natural Toxins - Wiley Online Library

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Article

Alkaloids of Stipa robusta (sleepygrass) infected with an Acremonium endophyte

  1. Richard J. Petroski1,
  2. Dr. Richard G. Powell1,*,
  3. Keith Clay2
Article first published online: 30 MAY 2006 DOI: 10.1002/nt.2620010205 Copyright © 1992 Wiley-Liss, Inc., A Wiley Company Issue

Natural Toxins

Volume 1, Issue 2, pages 84–88, March/April 1992 Additional Information(Show All) How to CiteAuthor InformationPublication History

How to Cite

Petroski, R. J., Powell, R. G. and Clay, K. (1992), Alkaloids of Stipa robusta (sleepygrass) infected with an Acremonium endophyte. Nat. Toxins, 1: 84–88. doi: 10.1002/nt.2620010205

Author Information

  1. 1Bioactive Constituents Research, U.S.D.A, Agricultural Research Service, National Center for Agricultural Utilization Research, Peoria, Illinois
  2. 2Department of Biology, Indiana University, Bloomington, Indiana
*Bioactive Constituents Research, U.S.D.A., Agricultural Research Service, National Center for Agricultural Utilization Research, 1815 North University Street, Peoria, IL 61604

Publication History

  1. Issue published online: 30 MAY 2006
  2. Article first published online: 30 MAY 2006
  3. Manuscript Accepted: 9 APR 1992
  4. Manuscript Received: 20 MAR 1992

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Keywords:

  • Fungal Endophytes;
  • Toxins;
  • Symbiosis;
  • Sedative;
  • New Mexico;
  • Grasses;
  • Grazing;
  • Horses

Abstract

Stipa robusta (= Stipa vaseyi) is a perennial grass found in certain areas of the southwestern United States. It is commonly known as sleepygrass, as horses that ingest this grass may become profoundly somnolent or stuporous for periods of time lasting up to several days. In an attempt to determine the active principle(s), fractionation of a methanolic extract of sleepygrass infected with an Acremonium endophyte has yielded lysergic acid amide (20 μg/g dry wt), isolysergic amide (8), 8-hydroxylysergic acid amide (0.3), ergonovine (7), chanoclavine-l (15), and N-formylloline (18). Related alkaloids have been found in many endophyte-infected grasses. The dominant alkaloid constituent in sleepygrass, lysergic acid amide, has not previously been identified in a grass in such high concentration. Lysergic acid amide is likely to be the basis for the extreme sedative effects on animals, given past pharmocological work on the compound from the ergot fungus Claviceps paspali. © 1992 Wiley-Liss, Inc. Get PDF (435K)

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