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AmiGO 2: Term Details for "G protein-coupled receptor signaling pathway" (GO:0007186)

AmiGO 2

G protein-coupled receptor signaling pathway

Term Information

Data health 
Accession
GO:0007186
Name
G protein-coupled receptor signaling pathway
Ontology
biological_process
Synonyms
G protein coupled receptor protein signaling pathway, G protein coupled receptor protein signalling pathway, G-protein coupled receptor protein signal transduction, G-protein coupled receptor protein signaling pathway, G-protein coupled receptor signalling pathway, G-protein-coupled receptor protein signalling pathway, GPCR signaling pathway, GPCR signalling pathway, G-protein coupled receptor signaling pathway via GPCR dimer, dimeric G-protein coupled receptor signaling pathway, dimeric G-protein coupled receptor signalling pathway
Alternate IDs
GO:0038042
Definition
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane. Source: Wikipedia:G_protein-coupled_receptor, PMID:24568158, PMID:16902576, GOC:bf, GOC:mah
Comment
None
History
See term history for GO:0007186 at QuickGO
Subset
None
Related
Link to all genes and gene products annotated to G protein-coupled receptor signaling pathway.
Link to all direct and indirect annotations to G protein-coupled receptor signaling pathway.
Link to all direct and indirect annotations download (limited to first 10,000) for G protein-coupled receptor signaling pathway.

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Parents of G protein-coupled receptor signaling pathway (GO:0007186)
subjectrelationobjectG protein-coupled receptor signaling pathway  RO:0002224  G protein-coupled receptor activity (GO:0004930) G protein-coupled receptor signaling pathway  is_a  signal transduction (GO:0007165)
Children of G protein-coupled receptor signaling pathway (GO:0007186)
subjectrelationobjectG protein-coupled purinergic receptor signaling pathway (GO:0035588)  is_a  G protein-coupled receptor signaling pathway cannabinoid signaling pathway (GO:0038171)  is_a  G protein-coupled receptor signaling pathway endothelin receptor signaling pathway (GO:0086100)  is_a  G protein-coupled receptor signaling pathway G protein-coupled acetylcholine receptor signaling pathway (GO:0007213)  is_a  G protein-coupled receptor signaling pathway protein kinase C-activating G protein-coupled receptor signaling pathway (GO:0007205)  is_a  G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187)  is_a  G protein-coupled receptor signaling pathway thromboxane A2 signaling pathway (GO:0038193)  is_a  G protein-coupled receptor signaling pathway apelin receptor signaling pathway (GO:0060183)  is_a  G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway involved in social behavior (GO:1904068)  is_a  G protein-coupled receptor signaling pathway octopamine or tyramine signaling pathway (GO:0007211)  is_a  G protein-coupled receptor signaling pathway sphingosine-1-phosphate receptor signaling pathway (GO:0003376)  is_a  G protein-coupled receptor signaling pathway G protein-coupled receptor signaling in absence of ligand (GO:0038035)  is_a  G protein-coupled receptor signaling pathway neuropeptide signaling pathway (GO:0007218)  is_a  G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway involved in defense response to Gram-negative bacterium (GO:1903554)  is_a  G protein-coupled receptor signaling pathway leukotriene signaling pathway (GO:0061737)  is_a  G protein-coupled receptor signaling pathway ion channel modulating, G protein-coupled receptor signaling pathway (GO:0099105)  is_a  G protein-coupled receptor signaling pathway phospholipase D-activating G protein-coupled receptor signaling pathway (GO:0031583)  is_a  G protein-coupled receptor signaling pathway cholecystokinin signaling pathway (GO:0038188)  is_a  G protein-coupled receptor signaling pathway thyroid-stimulating hormone signaling pathway (GO:0038194)  is_a  G protein-coupled receptor signaling pathway adrenergic receptor signaling pathway (GO:0071875)  is_a  G protein-coupled receptor signaling pathway gamma-aminobutyric acid signaling pathway (GO:0007214)  is_a  G protein-coupled receptor signaling pathway G protein-coupled glutamate receptor signaling pathway (GO:0007216)  is_a  G protein-coupled receptor signaling pathway gastric inhibitory peptide signaling pathway (GO:0038192)  is_a  G protein-coupled receptor signaling pathway luteinizing hormone signaling pathway (GO:0042700)  is_a  G protein-coupled receptor signaling pathway G protein-coupled receptor activity (GO:0004930)  BFO:0000050  G protein-coupled receptor signaling pathway follicle-stimulating hormone signaling pathway (GO:0042699)  is_a  G protein-coupled receptor signaling pathway regulation of G protein-coupled receptor signaling pathway (GO:0008277)  RO:0002211  G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway (GO:0007200)  is_a  G protein-coupled receptor signaling pathway G protein-coupled serotonin receptor signaling pathway (GO:0098664)  is_a  G protein-coupled receptor signaling pathway opioid receptor signaling pathway (GO:0038003)  is_a  G protein-coupled receptor signaling pathway somatostatin receptor signaling pathway (GO:0038169)  is_a  G protein-coupled receptor signaling pathway tachykinin receptor signaling pathway (GO:0007217)  is_a  G protein-coupled receptor signaling pathway calcitonin family receptor signaling pathway (GO:0097646)  is_a  G protein-coupled receptor signaling pathway rhodopsin mediated signaling pathway (GO:0016056)  is_a  G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway involved in heart process (GO:0086103)  is_a  G protein-coupled receptor signaling pathway phospholipase C-inhibiting G protein-coupled receptor signaling pathway (GO:0030845)  is_a  G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway involved in dauer larval development (GO:1904066)  is_a  G protein-coupled receptor signaling pathway ion channel regulator activity involved in G protein-coupled receptor signaling pathway (GO:0099107)  BFO:0000050  G protein-coupled receptor signaling pathway angiotensin-activated signaling pathway (GO:0038166)  is_a  G protein-coupled receptor signaling pathway positive regulation of G protein-coupled receptor signaling pathway (GO:0045745)  RO:0002213  G protein-coupled receptor signaling pathway negative regulation of G protein-coupled receptor signaling pathway (GO:0045744)  RO:0002212  G protein-coupled receptor signaling pathway bombesin receptor signaling pathway (GO:0031989)  is_a  G protein-coupled receptor signaling pathway complement component C5a signaling pathway (GO:0038178)  is_a  G protein-coupled receptor signaling pathway thrombin-activated receptor signaling pathway (GO:0070493)  is_a  G protein-coupled receptor signaling pathway
MIPS_funcat
30.01.05.05
30.05.02.24