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AmiGO 2: Term Details for "signal transduction" (GO:0007165)

AmiGO 2

signal transduction

Term Information

Data health 
Accession
GO:0007165
Name
signal transduction
Ontology
biological_process
Synonyms
signaling pathway, signalling pathway, signaling cascade, signalling cascade
Alternate IDs
GO:0023033
Definition
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. Source: GOC:mtg_signaling_feb11, GOC:go_curators
Comment
Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
History
See term history for GO:0007165 at QuickGO
Subset
goslim_metagenomics
goslim_aspergillus
goslim_chembl
goslim_plant
goslim_generic
goslim_candida
Related
Link to all genes and gene products annotated to signal transduction.
Link to all direct and indirect annotations to signal transduction.
Link to all direct and indirect annotations download (limited to first 10,000) for signal transduction.

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Parents of signal transduction (GO:0007165)
subjectrelationobjectsignal transduction  is_a  cellular process (GO:0009987) signal transduction  BFO:0000050  cell communication (GO:0007154) signal transduction  BFO:0000050  cellular response to stimulus (GO:0051716) signal transduction  BFO:0000050  signaling (GO:0023052) signal transduction  is_a  regulation of cellular process (GO:0050794)
Children of signal transduction (GO:0007165)
subjectrelationobjectendoplasmic reticulum unfolded protein response (GO:0030968)  is_a  signal transduction ER-nucleus signaling pathway (GO:0006984)  is_a  signal transduction SMAD protein signal transduction (GO:0060395)  is_a  signal transduction osmosensory signaling pathway (GO:0007231)  is_a  signal transduction positive regulation of signal transduction (GO:0009967)  RO:0002213  signal transduction mitochondria-nucleus signaling pathway (GO:0031930)  is_a  signal transduction intracellular signal transduction (GO:0035556)  is_a  signal transduction hypoxia-inducible factor-1alpha signaling pathway (GO:0097411)  is_a  signal transduction salicylic acid mediated signaling pathway (GO:0009863)  is_a  signal transduction signal transduction by protein phosphorylation (GO:0023014)  is_a  signal transduction hydrogen peroxide mediated signaling pathway (GO:0071588)  is_a  signal transduction defense response signaling pathway, resistance gene-independent (GO:0010204)  is_a  signal transduction signal transduction involved in positive regulation of conjugation with cellular fusion (GO:0032005)  is_a  signal transduction signal transduction involved in cellular response to ammonium ion (GO:1903831)  is_a  signal transduction negative regulation of signal transduction (GO:0009968)  RO:0002212  signal transduction cell surface receptor signaling pathway (GO:0007166)  is_a  signal transduction presynaptic signal transduction (GO:0098928)  is_a  signal transduction postsynaptic signal transduction (GO:0098926)  is_a  signal transduction hormone-mediated signaling pathway (GO:0009755)  is_a  signal transduction phototransduction (GO:0007602)  is_a  signal transduction cell cycle checkpoint (GO:0000075)  RO:0002230  signal transduction regulation of blood pressure by chemoreceptor signaling pathway (GO:0010850)  is_a  signal transduction lipoprotein particle mediated signaling (GO:0055095)  is_a  signal transduction bile acid signaling pathway (GO:0038183)  is_a  signal transduction sphingolipid mediated signaling pathway (GO:0090520)  is_a  signal transduction intracellular receptor signaling pathway (GO:0030522)  is_a  signal transduction necroptotic signaling pathway (GO:0097527)  is_a  signal transduction signal transduction involved in morphogenesis checkpoint (GO:1903822)  is_a  signal transduction carbohydrate mediated signaling (GO:0009756)  is_a  signal transduction defense response signaling pathway, resistance gene-dependent (GO:0009870)  is_a  signal transduction immune response-regulating signaling pathway (GO:0002764)  is_a  signal transduction programmed cell death (GO:0012501)  RO:0002224  signal transduction chloroplast-nucleus signaling pathway (GO:0010019)  is_a  signal transduction ligand-gated ion channel signaling pathway (GO:1990806)  is_a  signal transduction apoptotic signaling pathway (GO:0097190)  is_a  signal transduction G protein-coupled receptor signaling pathway (GO:0007186)  is_a  signal transduction peptidoglycan recognition protein signaling pathway (GO:0061057)  is_a  signal transduction signal transduction by conformational transition (GO:0023045)  is_a  signal transduction neuronal signal transduction (GO:0023041)  is_a  signal transduction extracellular ATP signaling (GO:0106167)  is_a  signal transduction signal transduction involved in regulation of gene expression (GO:0023019)  is_a  signal transduction receptor ligand activity (GO:0048018)  BFO:0000050  signal transduction calmodulin dependent kinase signaling pathway (GO:0099004)  is_a  signal transduction signal transduction involved in filamentous growth (GO:0001402)  is_a  signal transduction signal transduction in absence of ligand (GO:0038034)  is_a  signal transduction signal transduction involved in regulation of aerobic respiration (GO:1903759)  is_a  signal transduction regulation of signal transduction (GO:0009966)  RO:0002211  signal transduction red or far-red light signaling pathway (GO:0010017)  is_a  signal transduction regulation of floral organ abscission by signal transduction (GO:0060863)  is_a  signal transduction
MIPS_funcat
30
Wikipedia
Signal_transduction