Toward Automatic Reconstruction of a Highly Resolved Tree of Life

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Title:
Toward Automatic Reconstruction of a Highly Resolved Tree of Life Authors:
Ciccarelli, Francesca D.; Doerks, Tobias; von Mering, Christian; Creevey, Christopher J.; Snel, Berend; Bork, Peer Affiliation:
AA(European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany.; Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy.), AB(European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany.), AC(European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany.), AD(European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany.), AE(Center for Molecular and Biomolecular Informatics, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Toernooiveld 1, 6525 ED, Nijmegen, Netherlands.), AF(European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany.; Max Delbrück Centrum, 13092 Berlin-Buch, Germany.) Publication:
Science, Volume 311, Issue 5765, pp. 1283-1287 (2006). (Sci Homepage) Publication Date:
03/2006 Category:
EVOLUTION Origin:
SCIENCE Abstract Copyright:
(c) 2006: Science DOI:
10.1126/science.1123061 Bibliographic Code:
2006Sci...311.1283C

Abstract

We have developed an automatable procedure for reconstructing the tree of life with branch lengths comparable across all three domains. The tree has its basis in a concatenation of 31 orthologs occurring in 191 species with sequenced genomes. It revealed interdomain discrepancies in taxonomic classification. Systematic detection and subsequent exclusion of products of horizontal gene transfer increased phylogenetic resolution, allowing us to confirm accepted relationships and resolve disputed and preliminary classifications. For example, we place the phylum Acidobacteria as a sister group of delta-Proteobacteria, support a Gram-positive origin of Bacteria, and suggest a thermophilic last universal common ancestor.
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